The University of Pretoria (UP) is pioneering a breakthrough in wound care that could transform the treatment of burns and chronic injuries. Researchers from UP’s Departments of Anatomy and Pharmacology have developed a method to 3D bioprint artificial skin, offering a potentially game-changing alternative to traditional skin grafting.
Wound healing has been described as a “silent epidemic,” not only for its human toll but also for the immense strain it places on healthcare systems. Secondary intent wounds—those left open to heal naturally, such as burns—are typically treated with skin grafts, but this method has limitations. It relies heavily on the patient’s condition, the availability of donor skin, and risks immune rejection.
To overcome these challenges, UP researchers have focused on developing decellularised acellular dermal scaffolds (ADS)—a substitute for skin grafts created by removing cells from donor or animal skin to minimise rejection. However, traditional methods of producing ADS can damage the structure and reduce its strength.
Enter 3D bioprinting.
“Emerging technologies like 3D bioprinting allow us to create more accurate and durable skin substitutes,” says Dr Alison Ridel from the Department of Anatomy. “Our research developed a digital protocol for printing 3D acellular dermal scaffolds tailored for wound healing.”
The project brought together experts in biology, engineering, and computational science. Using advanced tools like micro-x-ray computed tomography and Amira-Avizo software, the team was able to design precise, high-quality scaffolds that replicate the properties of natural human skin.
According to researcher Hafiza Parkar, the impact of this innovation is significant.
“These scaffolds can be customised for the size, depth, and nature of each patient’s wound,” she explains. “This personalised approach speeds up healing and reduces complications, easing both the physical and psychological burden on patients.”
Beyond its medical benefits, the technique also offers a more sustainable, cost-effective solution. The precision of 3D bioprinting reduces material waste and allows for scalable production, potentially making advanced wound care more accessible to those in need.
“Effective wound healing isn’t just about recovery—it’s about restoring dignity, reducing infection risk, and improving quality of life,” Parkar adds.
UP’s innovative use of 3D bioprinting in wound care represents a major leap forward in reconstructive medicine, offering new hope for patients and healthcare providers alike.
